What are the side effects of Clomid

Clomiphene - hormone treatment if you want to have children

Success rate with clomiphene

The success rate for treatments with clomiphene is usually quite high: studies have shown that women with ovulation problems have a 70/80% chance of ovulation success [4] [5]. The chances of subsequently becoming pregnant are around 30-40% [6] [8].

The role of age
As you probably already know, a number of factors affect a woman's fertility. One of the biggest factors is age. For women over 35 years of age, clomiphene can only be helpful if a sufficient number of egg cells is available in advance. If the supply of existing egg cells is too low, the drug may not be successful [6].

Special case PCOS: letrozole vs. clomiphene

As Alternative therapy forPCOS- Patients should be Letrozole show a "more favorable side effect profile". Furthermore, there is usually singular follicular maturation, which means a slightly lower rate of multiple pregnancies overall [10].

According to the official international PCOS recommendation guideline The probability of multiple pregnancies in women with polycystic ovarian syndrome is lower with letrozole than with clomiphene [11].

The twin pregnancy rate could be compared in a study between the groups with clomiphene and letrozole. The twin pregnancy rate among pantint women receiving clomiphene is slightly higher (7.4%) than among those receiving letrozole (3.4%) [10].

Letrozole and clomiphene are the first choice for ovulating in women with PCOS and are therefore considered to be "First-line therapy". 
In Germany, the drug letrozole has so far only been approved for the treatment of breast cancer. It is therefore used "off-label" for fertility treatments [11].

Women with PCOS are more likely to ovulate with letrozole than with clomiphene. However, there is still no evidence that letrozole is more effective in women without PCOS.

In PCOS patients, treatment with letrozole compared to clomiphene resulted in a higher pregnancy rate (per patient and per cycle) [11]. The live birth rate was also higher in the letrozole group than in the clomiphene group [10] [11].

Genadotropins can as "Second Line Therapy" can be used when clomiphene or letrozole could not achieve the desired result [11].

If the attempt to induce ovulation is unsuccessful, the third option is, for example, artificial insemination using IVF or ICSI [11].

Side effects of clomiphene

During clomiphene treatment, more than 1 in 10 women may experience flushing, hot flashes, and ovarian enlargement [2]. Other side effects can occur in rare cases, but can be found on the accompanying leaflet or from your doctor. In addition, treatment with clomiphene can lead to the so-called "ovarian hyperstimulation syndrome".

When taking clomiphene, there is an increased likelihood of multiple pregnancies (6-8%) [1] [8].

Problems with multiple pregnancies

The rate of multiple pregnancy is lower with aromatase inhibitor treatments Letrozole lower than compared to clomiphene [10].

The problem with multiple pregnancies during pregnancy lies in the risks of premature birth, the increased risk of premature death and the so-called "intrauterine growth restriction", which means that the fetus does not achieve the genetic growth potential.
For pregnant women, too, multiple pregnancies are associated with an increased number of different, increased risks.
Medical supervision and supervision are therefore important in order to avoid complications.